The group said the job cuts come as part of a management overhaul under plans to save £330 million over the next two years.
The cull will affect some of its 9,700 managers, with senior executive and non-operational roles hardest hit.
Keith Williams, interim executive chairman at Royal Mail Group, said the firm is taking “immediate action” on costs to offset the Covid-19 impact.
He said: “In recent years, our UK business has not adapted quickly enough to the changes in our marketplace of more parcels and fewer letters.
“Covid-19 has accelerated those trends, presenting additional challenges.”
On the job cuts, he said: “We are committed to conducting the upcoming consultation process carefully and sensitively.
“We will work closely with our managers and their representatives during this difficult period.”
Additional reporting by PA